Who are ‘the good, bad and ugly’ in the echinocandins versus triazoles discussion?

This blog explores what the optimal antibiotic prophylaxis for cardiac surgery should look like, based on the following questions. 1. When should antibiotic prophylaxis be administered in cardiac surgery? 2. Which antibiotic coverage is required for prophylaxis in cardiac surgery?

1. Why it might be a good idea to treat E. faecalis with combination therapy? 2. What is the clinical evidence for combination therapy in E. faecalis endocarditis? 3. What is the clinical evidence for combination therapy in isolated E. faecalis bacteremia?

1. What are internal flaws of the PROSTASHORT trial? 2. Which evidence came out since the start of the PROSTASHORT trial?

1. Which factors play a role in determining the dosing of ceftriaxone? 2. What is the standard dose of ceftriaxone: 1 or 2 grams once daily, or 1 gram twice daily? 3. In which situations might more than 2 gram of ceftriaxone be beneficial

1. What are the risks and benefits associated with intrathecal antibiotic therapy? 2. What are the main uncertainties surrounding intrathecal antibiotic therapy?

This finding could be important to boost individual vaccination response, especially in this age of declining vaccination uptake and thus decreased herd immunity. Moreover, maybe there were other ways to boost individual vaccine response (beside having an excellent vaccine) 1. Is there a diurnal effect in the immune response to vaccination? 2. Are there other environmental factors that might influence vaccine response? 2. Are there other environmental factors that might influ