Antimicrobial resistance poses a growing global threat to public health, directly causing an estimated 1.27 million deaths in 2019 alone (1). In clinical practice, this rise in resistance means clinicians will increasingly encounter infections where carbapenems - the once, reliable last-line agents - are ineffective. Since resistance mechanisms can often be determined before susceptibility results are available, this blog provides a schematic overview of beta-lactam treatment

1. What was the impact of the MERINO study on treatment approaches of ESBL-producing infections? 2. Why MERINO study’s intrinsic flaws may invalidate its conclusions? 3. How to deal with the results from the MERINO study?

1. What is the role of corticosteroids in treating influenza? 2. Should antibiotics - particularly macrolides - be used for severe influenza infections? 3. What evidence exists for other therapies in influenza-related ARDS

New retrospective studies continue to claim that each hour delay in antibiotic administration significantly increases mortality in sepsis and septic shock, implying that any patient with a hint of sepsis should receive antibiotics immediately. However, both sepsis and septic shock can present with widely variable clinical features, making diagnosis challenging. This blog explores the current evidence regarding the time to antibiotic administration in sepsis and septic shock.

Who are ‘the good, bad and ugly’ in the echinocandins versus triazoles discussion?

This blog explores what the optimal antibiotic prophylaxis for cardiac surgery should look like, based on the following questions. 1. When should antibiotic prophylaxis be administered in cardiac surgery? 2. Which antibiotic coverage is required for prophylaxis in cardiac surgery?

1. Why it might be a good idea to treat E. faecalis with combination therapy? 2. What is the clinical evidence for combination therapy in E. faecalis endocarditis? 3. What is the clinical evidence for combination therapy in isolated E. faecalis bacteremia?