

What to do with the results of the PROSTASHORT trial?
1. What are internal flaws of the PROSTASHORT trial?
2. Which evidence came out since the start of the PROSTASHORT trial?
38 minutes ago7 min read


Ceftriaxone dosing: 1, 2, 3 or 4 grams daily?
1. Which factors play a role in determining the dosing of ceftriaxone?
2. What is the standard dose of ceftriaxone: 1 or 2 grams once daily, or 1 gram twice daily?
3. In which situations might more than 2 gram of ceftriaxone be beneficial
Jul 196 min read


Is intraventricular antibiotic therapy ready for prime time?
1. What are the risks and benefits associated with intrathecal antibiotic therapy? 2. What are the main uncertainties surrounding intrathecal antibiotic therapy?
Jun 287 min read


Vaccination: better early than late
This finding could be important to boost individual vaccination response, especially in this age of declining vaccination uptake and thus decreased herd immunity. Moreover, maybe there were other ways to boost individual vaccine response (beside having an excellent vaccine)
1. Is there a diurnal effect in the immune response to vaccination?
2. Are there other environmental factors that might influence vaccine response?
2. Are there other environmental factors that might influ
May 315 min read


What to do in case of isolated anti-hepatitis B core antibodies in HIV?
1) What does the presence of isolated anti-HBc antibodies mean? 2) What to do in case of isolated anti-HBc antibodies? 3) How to manage a HIV infection with isolated anti-HBc antibodies?
May 316 min read


Stenotrophomonas maltophilia: The common but unknown story
This article discusses 1) Why we don't have a good idea how to treat Stenotrophomonas maltophilia; 2) Whether S. maltophilia should always be treated by combination therapy; 3) What are the best ways to treat S. maltophilia
Apr 138 min read


Pathophysiology of Neutropenic Fever: Impact on Diagnosis and Treatment
Febrile neutropenia is a medical emergency marked by fever and low neutrophil count, often after cytoreductive therapy. Its pathophysiology involves neutropenia and mucosal barrier injury, which can cause fever without infection. Persistent fever doesn’t always mean antibiotic failure; mucositis and inflammation are common causes. Diagnosis should focus on fungal infection screening and selective blood cultures. A broad differential remains essential to guide management.
Apr 27 min read