Initiating antibiotics in sepsis: when late becomes too late
New retrospective studies continue to claim that each hour delay in antibiotic administration significantly increases mortality in sepsis and septic shock, implying that any patient with a hint of sepsis should receive antibiotics immediately. However, both sepsis and septic shock can present with widely variable clinical features, making diagnosis challenging. This blog explores the current evidence regarding the time to antibiotic administration in sepsis and septic shock.
1 hour ago10 min read
Are Echinocandins superior to Triazoles for the treatment of invasive candidiasis?
Who are ‘the good, bad and ugly’ in the echinocandins versus triazoles discussion?
Oct 297 min read
Optimizing Antibiotic prophylaxis in Cardiac Surgery: Evidence and Best Practices
This blog explores what the optimal antibiotic prophylaxis for cardiac surgery should look like, based on the following questions.
1. When should antibiotic prophylaxis be administered in cardiac surgery?
2. Which antibiotic coverage is required for prophylaxis in cardiac surgery?
Oct 185 min read
Combination Therapy for Enterococcal Bacteremia: Is 2 better than 1?
1. Why it might be a good idea to treat E. faecalis with combination therapy?
2. What is the clinical evidence for combination therapy in E. faecalis endocarditis?
3. What is the clinical evidence for combination therapy in isolated E. faecalis bacteremia?
Sep 307 min read